email@example.comGrowth, Development and Metabolism Programme
Adjunct Senior Investigator
- Assistant Professor, Psychiatry/Neurology, McGill University, 1984-1991
- Associate Professor, Psychiatry/Neurology, McGill University, 1991-1996
- Full Professor, Psychiatry/Neurology, McGill University, 1996-Current
- James McGill Chair, Medicine, McGill University, 2000-Current
- Co-Director, Sackler Program for Epigenetics, 2008
- Adjunct Senior Investigator, Singapore Institute for Clinical Sciences A*STAR (Singapore), 2008
- Cognitive function
- Gene expression
- Hormone receptor biochemistry
- Receptor signalling
- Gene expression
- Parental behaviour
Loyola College BSc Biology/Psychology, 1975
Concordia University MA Clinical Psychology, 1977
Concordia University PhD Neuroscience, 1981
The Rockefeller University PDF Neuroendocrinology, 1984
NSERC University Research Fellowship Career Award 1983
MRCC Scientist Award Career Award 1991
MRCC Senior Scientist Award Career Award 1997
American Psychosomatic Society Patricia R. Barchas Award in Sociophysiology 2000
NARSAD Distinguished Investigator Award 2002
James McGill Chair, Medicine 2002
Bank of Montreal Fellow Cdn. Inst. Adv. Res. 2005
Heinz Lehmann Award Cdn. College Neuropsychopharmacology 2005
Presidential Scholar Univ. of California, San Francisco 2005
Klerman Award Cornell University 2006
"Highly Cited" Scientist (Neuroscience) Institute for Scientific Information 2007
Peter Lougheed Prize Alberta Heritage Fund for Medical Research 2008
McGowan PO et al. Epigenetic regulation of hippocampal glucocorticoid receptor gene expression associates with childhood abuse in human suicide victims. Nature (Neuroscience), In press.
McGowan PO et al. Differential methylation of a neuron-enriched glucocorticoid receptor gene promoter in human hippocampus is associated with early child trauma and adult psychopathology. Submitted.
Cameron N et al. Maternal regulation of individual differences in reproductive behavior and endocrine systems in the rat. PlosOne, 2008, 3:e2210.
Champagne DL et al. Maternal care alters dendritic length, spine density and synaptic potentiation in adulthood. Journal of Neuroscience, 2008, 28: 6037-6045.
McGowan PO et al. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PlosOne, 2008, 3:e2085.
Pruessner JC et al. Deactivation of the limbic system during psychosocial stress: Evidence from PET and fMRI studies. Biological Psychiatry, 2008, 63, 234-240.
Meaney MJ. Social influences on sexual differentiation in mammals. Advances in Genetics, 2007, 59, 17215.
Buss C et al. Maternal care modulates the relationship between prenatal risk and hippocampal volume. Journal of Neuroscience, 2007, 27: 2592-2595.
de Vries A et al. Prenatal dexamethasone exposure induces offspring metabolic and hypothalamic-pituitary-adrenal axis changes without alteration of birth weight in a non-human primate, C. aethiops. Journal of Clinical Investigation, 2007, 117, 1058-1067.
Meaney et al. Epigenetic mechanisms of perinatal programming of hypothalamic-pituitary-adrenal function and health. Trends in Molecular Medicine. 2007, 13, 269-277.
Champagne FA et al. Maternal care regulates methylation of the estrogen receptor alpha 1b promoter and estrogen receptor alpha expression in the medial preoptic area of female offspring. Endocrinology, 2006, 147, 2909-2915.
Meaney MJ, Szyf M. Maternal effects as a model for environmentally-dependent chromatin plasticity. Trends in Neuroscience, 2005, 28, 456-463.
Weaver IC et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. Journal of Neuroscience. 2005, 25,11045-11054.
Pruessner JC et al. Self-esteem, locus of control, hippocampal volume, and cortisol regulation in young and old adulthood. Neuroimage, 2005, 28, 815-826.
Szyf M et al. Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat. Frontiers in Neuroendocrinology, 2005, 26, 139-162.
Weaver et al. Epigenetic programming through maternal behavior. Nature (Neuroscience), 2004, 7, 847-854.
Pruessner JL et al. Parental care and neuroendocrine and dopamine responses to stress in humans: A PET imaging study. Journal of Neuroscience, 2004, 24 2825-2831.
Champagne FA et al. Variations in maternal care in the rat are associated with differences in estrogen-related changes in oxytocin receptor levels. Proceedings of the National Academy of Science. 2001, 98, 12736-12741.
Meaney MJ et al., Handling alters the expression of messenger RNAs for AP-2, NGFI-A and NGFI-B in the hippocampus of neonatal rats. Journal of Neuroscience, 2000, 20, 3936-3935.
McCormick JA et al. 5'Heterogeneity of glucocorticoid receptor messenger ribonucleic acid is tissue-specific: Regulation of variant transcripts by early life events. Molecular Endocrinology, 2000, 14, 506-517.
Liu D et al. Maternal care, hippocampal synaptogenesis and cognitive development in the Rat. Nature (Neuroscience), 2000, 3, 799-806.
Francis DD et al. Nongenomic transmission across generations in maternal behavior and stress responses in the rat.. Science, 1999, 286, 1155-1158.
Lupien SJ et al. cortisol levels and impaired cognition in human aging: Implications for depression and dementia in later life. Reviews in Neurosciences, 1999, 10, 117-139.
Lupien S et al. Glucocorticoids and human brain aging. Nature (Neuroscience), 1998, 1: 69-73.
Liu D et al. Maternal care, hippocampal glucocorticoid receptors and HPA responses to stress. Science, 1997, 277, 1659-1662.